for advanced research in life sciences
Ultrastructural Volume Analysis
Cryo-ET Sample Preparation
Prepare vitrified lamellae with precision to support high-quality cryo-electron tomography
High-quality cryo-ET data depends on producing thin, artifact-free lamellae from vitrified specimens while maintaining cryogenic conditions throughout the workflow. Tescan Ga⁺ FIB-SEM delivers precise, site-specific milling ideal for targeted preparation of small or complex regions of interest, while Tescan plasma FIB-SEM offers rapid thinning of larger volumes—reducing time to result for larger specimen. Both platforms are fully cryo-optimized, integrating dedicated cryo-stage, anti-contamination, and transfer solutions to protect sample integrity. This combination enables researchers to match the right FIB-SEM and workflow to their specimen type, balancing precision and speed for reliable cryo-ET investigations.
Surface Morphology Analysis
Examine external biological features with high-contrast SEM imaging tailored for delicate specimens
In zoology and plant science, surface structures often hold critical information about an organism’s function, adaptation, and taxonomy. From the micro-patterns on insect exoskeletons that influence aerodynamics or camouflage, to the texture of plant surfaces that affect water retention and pathogen resistance, fine morphological detail is key to understanding biological performance and evolution. Studying these surfaces at high magnification allows researchers to connect form with function, trace evolutionary relationships, and document biodiversity with accuracy beyond the limits of light microscopy. Tescan offers a range of SEMs highly
for every electron microscopy
workflow
TESCAN AMBER
Ga⁺ FIB-SEM optimized for cryo-TEM lamella preparation of vitrified biological samples.TESCAN AMBER enables precise on-grid and lift-out cryo-TEM sample prep from plunge- or high-pressure frozen specimens. The Orage™ Ga FIB ensures artifact-free milling, while integrated cryo manipulators and compatibility with Leica and Quorum systems support safe, repeatable workflows from vitrification to TEM transfer.
- Produces clean, ultra-thin cryo lamellae without curtaining using integrated Orage™ FIB and cryo sample handling.
- Simplifies training and improves reproducibility with guided cryo lift-out workflows and collision-safe navigation.
- Minimizes contamination and sample loss through seamless integration with leading cryo transfer and prep systems.
TESCAN SOLARIS X 2
Universal Xe Plasma FIB-SEM for high-throughput cryo-TEM preparation and 3D volume EM.SOLARIS X 2, powered by Mistral™ Xe plasma FIB, delivers fast, low-damage cryo milling and artifact-free large-volume sectioning of soft and hard biological specimens. Integrated with TESCAN’s Rocking Stage, Cryo Nanomanipulator, and modular Essence™ software, it supports multimodal cryo and ambient 3D Analysis as well as Cryo TEM specimen preparation, ideal for shared Life Science facilities.
- Enables clean, repeatable cryo lamella specimen prep and 3D EM analysis with high-current Xe FIB and Rocking Stage artifact suppression.
- Reduces operator variability with intuitive, guided cryo workflows—ideal for multi-user environments.
- Supports cryo lift-out, multimodal correlative prep, and in-situ cryo imaging with Leica and Quorum system compatibility.
TESCAN CLARA
UHR SEM platform for volume EM imaging via Serial Block-Face and Array Tomography.TESCAN CLARA brings sub-nanometer resolution and low-keV contrast imaging to 3D biological imaging workflows. Compatible with in-chamber ultramicrotomy and external array tomography, CLARA provides high-quality volume data from resin-embedded samples, optimized for sensitive tissues such as brain or organoid structures.
- Enables high-contrast, damage-free imaging of resin-embedded samples with dedicated low-keV BSE detection.
- Supports both SBF-SEM and array tomography workflows with modular, easily exchangeable hardware.
- Extends conventional SEM capability into 3D volume EM with minimal system modifications or downtime.